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When Wrinkle Relaxers Stop Working: Could Xeomin® Be the Answer?

  • Writer: LaceyLuminousSkin
    LaceyLuminousSkin
  • Mar 14
  • 4 min read

Updated: Jun 24

Looking for the best way to smooth fine lines and keep your skin looking fresh?  While Botox® is widely known, many people don’t realise that over time, it can become less effective as the body builds resistance. That’s why at Luminous Skin, your results and long-term skin health always come first.


I choose Xeomin®, a next-generation wrinkle relaxer - because it delivers the same smoothing effects as Botox®, but without unnecessary proteins that can lead to resistance. This means you’ll enjoy consistently natural, long-lasting results without worrying about your treatment becoming less effective over time.


Xeomin® is a next-generation alternative that offers purer, longer-lasting results
Xeomin® is a next-generation alternative that offers purer, longer-lasting results

Here’s what you’ll learn in this guide:


If you're thinking about anti-wrinkle injections, keep reading to discover why I choose Xeomin® over Botox® at Luminous Skin - and why my clients love their results!



What are Xeomin® and Botox®?


Both Xeomin and Botox are injectable wrinkle relaxers made from botulinum toxin type A. They soften lines and wrinkles by temporarily relaxing the muscles that cause them. These treatments are great for reducing signs of aging and preventing deeper lines from forming.


A Few of the Common Treatment Areas:

✔ Frown lines (between the eyebrows)

✔ Forehead lines (horizontal wrinkles across the forehead)

✔ Crow’s feet (fine lines around the eyes)


Check out real results with our before & after photos here!



Xeomin® vs. Botox®: What’s the Difference?


While Botox and Xeomin work in similar ways, there’s one major difference: Xeomin is a more purified version of botulinum toxin. Unlike Botox, it doesn’t contain accessory proteins, which means your body is less likely to develop resistance over time. This is a huge plus for anyone who wants long-term, reliable results!


Xeomin® vs. Botox®: Quick Comparison


Contains Extra Proteins?

  • Xeomin®: No - It's a pure form of botulinum toxin without complexing proteins.

  • Botox®: Yes - Contains additional proteins that may trigger resistance.


Risk of Resistance?

  • Xeomin®: Very low risk due to its purified formula.

  • Botox®: Resistance can develop over time with repeated use.


Storage Needs:

  • Xeomin®: Stable at room temperature, making it easier to store.

  • Botox®: Requires refrigeration prior to use.


Results Show In:

  • Xeomin®: Typically within 3–4 days.

  • Botox®: Typically within 3–4 days.


How Long Does It Last?

  • Xeomin®: Effects last around 3–4 months.

  • Botox®: Effects last around 3–4 months.



Understanding Botox® Resistance: What You Need to Know


Did you know? Some Botox users report needing higher doses or noticing weaker effects over time. This is due to a phenomenon known as botulinum toxin resistance.


What is Botox® Resistance?


Resistance occurs when the immune system starts neutralising the botulinum toxin, making treatments less effective. You may notice:


▪ Shorter-lasting results – Effects fade faster than usual

▪ Increased dosage requirements – You need more units to see the same effect

▪ Weaker muscle relaxation – Wrinkles aren’t as smooth as they used to be

Complete treatment failure – In rare cases, Botox® stops working entirely


What Causes Botox® Resistance?


Complexing Proteins in Botox – The additional proteins in Botox can trigger an immune response, leading to resistance.

Frequent or High-Dose Treatments – Receiving too many injections too often can accelerate antibody development.

Long-Term Use – Regular Botox treatments over several years can gradually make the body more resistant.



What Makes Xeomin® Wrinkle Relaxers Different?


 100% Pure Formula – Unlike Botox, Xeomin is a “naked” neurotoxin, meaning it contains only the active botulinum toxin and nothing else. This means your body isn’t exposed to unnecessary proteins that could trigger an immune response.


  No Resistance Build-Up – Because Xeomin is free from complexing proteins, your body won’t develop antibodies against it. This means your results will remain consistent over time.


  Smooth, Natural Results – Just like Botox, Xeomin works by relaxing facial muscles to smooth wrinkles. But because it doesn’t contain extra additives, you get a more natural, refreshed look.


  Long-Lasting Effects – Results appear in 3-4 days and typically last 3-4 months, keeping you looking youthful and radiant.


Crow’s feet Treatment (fine lines around the eyes)
Crow’s feet Treatment (fine lines around the eyes)

FAQs About Xeomin® and Botox®


1. Does Xeomin last as long as Botox?

Yes! Both treatments last approximately 3-4 months before needing a touch-up.


2. How soon will I see results from Xeomin?

Xeomin results typically appear within 3-4 days, just like Botox.


3. Can I switch from Botox to Xeomin?

Absolutely! Many clients who have developed Botox resistance successfully switch to Xeomin for better, longer-lasting results.


4. Is Xeomin more natural-looking than Botox?

Yes! Because Xeomin doesn’t contain complexing proteins, it often results in a softer, more natural appearance.


5. Who is a good candidate for Xeomin?

Anyone looking to reduce fine lines and wrinkles while avoiding Botox resistance is an excellent candidate for Xeomin.


6. How do I know if I have Botox resistance?

If you’ve noticed that Botox doesn’t last as long or requires higher doses, you may have developed resistance. In that case, Xeomin is an ideal alternative.



Ready to Experience the Xeomin® Difference?


If you want long-lasting, natural-looking wrinkle reduction - without the risk of Botox resistance - Xeomin is your best option!


Book your consultation today at Luminous Skin! Let’s create a customised treatment plan tailored to your beauty goals.




Note: We ensure that all our advertising and content about cosmetic treatments, comply with the guidelines set forth by the relevant authorities. Your safety and satisfaction are our top priorities.


Mandatory Statements:

Botox®, Prescription Medicine. For the treatment of frown lines and crow’s feet round the eyes. Botox® has risks and benefits. Ask your doctor if Botox is right for you. Botulinum toxin type A 50, 100, 200 Units. For product information check with your doctor or Consumer Medicine Information on medsafe.govt.nz for further details. Allergan, Auckland.


Xeomin® (incobotulinum toxin ) Prescription Medicine for the treatment of upper facial lines: glabellar frown lines, crow’s feet round the eyes, horizontal forehead lines. Xeomin has risks and benefits. Ask your doctor if Xeomin is right for you (incobotulinum toxin A, purified Botulinum toxin type A 50 Units and 100 Units. For product information check with your doctor or Consumer Medicine Information on medsafe.govt.nz. Merz, Sydney. Distributed by Healthcare Logistics, Auckland.

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